Shockwave therapy has emerged as a valuable non-invasive modality, with an absence of surgical risks.

Shockwave Technology 
in orthopedics

In the complex world of orthopedic care, while surgical interventions remain a mainstay, the potential of adjuvant therapies such as Shockwave Therapy is recognized as complementary tool that enhances the continuum of care. Shockwave, as an adjunctive modality, is grounded in research, works in tandem with primary treatments to optimize healing, pain management, and rehabilitation, enriching the holistic approach of orthopedic practice.


While fracture healing remains a documented benefit of Shockwave Therapy, a considerable volume of orthopedic research has pivoted towards its application in managing tendinopathies, fasciopathies, and other soft tissue ailments of both the upper and lower extremities. Shockwave therapy’s benefits have been observed in numerous orthopedic conditions. Over 256 studies  have shown the benefits of Shockwave Therapy in Orthopedic Practice.

Central to its healing mechanism is its capacity to:
Encourage neovascularization at the tendon-bone junction.
Stimulate tenocyte proliferation and osteoprogenitor differentiation.
Intensify leukocyte infiltration.
Enhance growth factor and protein synthesis, thereby driving collagen production and tissue remodeling.

The Following Effects have been Investigated and Confirmed:

Angiogenesis Promotion: Shockwave Therapy has been demonstrated to influence angiogenesis  by modulating various factors, including:
Von Willebrand factor (vWF)
Vascular endothelial growth factor (VEGF)
Endothelial nitric oxide synthase (eNOS)
Proliferating cell nuclear antigen (PCNA)

Anti-inflammatory Effects: The treatment showcases powerful anti-inflammatory properties, modulating molecules like:
Soluble intercellular adhesion molecule 1 (sICAM)
Soluble vascular cell adhesion molecule 1 (sVCAM)

Wound Healing: Shockwave Therapy accelerates wound healing, influenced by factors such as Wnt3, Wnt5a, and β-catenin,

Bone Healing and bone recovery 2 (Moya) through factors like:
Bone morphogenetic protein (BMP)
Stimulation of  tenocyte proliferation and osteoprogenitor differentiation
Alkaline phosphatase
Dickkopf-related protein 1 (DKK-1)
Insulin-like growth factor (IGF)

Regenerative Properties: Apart from promoting functional proteins that foster a chondroprotective effect, shockwave therapy aids in:
Tissue and nerve regeneration 1(Wang)

1Dr.  C.J. Wang  FS   Shockwave Therapy induces neovascularization at the tendon bone junction. A study on Rabbits  Journal of Orthopedic Research 2003 Nov; 21 (6): 984-9

Immunomodulation: A unique feature of shockwave therapy is its ability to induce a shift in the macrophage phenotype from M1 to M2 and augment T-cell proliferation, enhancing the body’s immunomodulatory capabilities.
Inflammation Modulation and Muscle Treatment: The therapy activates the TLR3 signaling pathway, adjusting the expression of interleukins like IL-6, leading to improved treatment outcomes for ischemic muscles.

Restorative Medicine

In vitro studies show that Hyaluronic Acid (HA), Platelet-Rich Plasm (PRP) and shockwave promote regeneration and attenuate human chondrocyte degeneration of osteoarthritic cells explanted by patients subjected to total hip replacement. In addition, we show for the first time that ESWT-mediated increase of CD44 expression enhances their susceptibility to HA treatment. Shockwave, HA and PRP can help manage restrictions affecting cartilage repair capacity, confirming a possible relationship in the pathways involved in the dedifferentiation and senescence of human chondrocytes.

Ready to Add a Shockwave Therapy Device to Your Practice


See the evidence from studies conducted with shockwave technology.

2 The Role of Extracorporeal Shockwave Treatment in Musculoskeletal Disorders

Daniel Moya, MD, Silvia Ramon, MD, PhD, Wolfgang Schaden, MD, Ching-Jen Wang, MD, Leonardo Guiloff, MD, and Jai-Hong Cheng, MD  

Efficacy of Extracorporeal Shockwave Therapy in Frozen Shoulder

Babak Vahdatpour, Parisa Taheri, Abolghasem Zare Zade, Saeed Moradian

Extracorporeal Shockwave Therapy Compared with Surgery for Hypertrophic Long – Bone Nonunions

Angelo Cacchio, MD, Lucio Giordano, MD, Olivo Colafarina, MD, Jan D. Rompe, MD, Emanuela Tavernese, MD, Francesco Ioppolo, MD, Stefano Flamini, MD, Giorgio Spacca, MD, and Valter Santilli, MD

Shockwave Results


Improved for Plantar Fasciitis


Improvement for Calcific Tendonitis of the shoulder


Improvement for Tennis Elbow 
(Lateral Epicondylitis)


Improvement for Achilles


Relief for Myofascial Trigger Point


Improvement for Patellar Tendonitis (Jumper’s Knee)


Improvement for Hamstring Injuries



Interested in Getting a Quote?

Please enter your details and we’ll contact you shortly.


1 (844) 636-9283

Please enable JavaScript in your browser to complete this form.

Buy Shockwave Therapy Machines

Discover how you can start augmenting patient care and grow your practice with shockwave therapeutic machines. Contact us today for available shockwave machines and costs.

Please enable JavaScript in your browser to complete this form.